Product · Differential

The reasoning your registrar would do — if they had the whole night.

Differential ingests pathology, imaging, scripts and history. It generates ranked diagnoses with confidence, cites the evidence chain, and runs a self-critique pass to catch what a tired clinician would.

FHIR ingestSNOMED-CT codedReasoning trace per caseTGA-aligned
CASE #A-2847 · REASONING ACTIVEt+00:04.2s
Pathology
CRP 84, WCC 14.2, LFTs mildly deranged
▲ trending up (vs 2wk)
Imaging
CT abdo — gallbladder wall thickening, pericholecystic fluid
read in context
History
F/58, RUQ pain 3 days, postprandial, fever overnight
via Socrates pre-visit
Medications
Metformin, atorvastatin, no anticoagulants
no interactions flagged
PRIMARY
Acute cholecystitis
conf 0.87
Murphy's + (hx)CRP elevatedWall thickeningPostprandial
Ascending cholangitis
conf 0.34
LFT derangementFeverno jaundice yet
Self-critique: Charcot's triad incomplete. Recommend serial LFTs + MRCP if trending.
Peptic ulcer disease
conf 0.11
pain location atypicalimaging not supportive
What Differential does

Four steps. One loop. Your judgement, not replaced — amplified.

01 · INGEST
It reads the whole chart — not just the referral.
Pulls pathology, imaging reports, prescriptions, and longitudinal history over HL7/FHIR. Trends across visits, not just today's snapshot. Understands when a “normal” result is abnormal for this patient.
Works with Best Practice, MedicalDirector, Genie, Cerner
02 · REASON
Generates a ranked differential with confidence it will stand behind.
Every candidate carries a probability, the specific findings that support it, and the ones that don't. Not a vibe — a structured argument, in under five seconds.
Average 4.1s per case · GPT-class reasoning + clinical guardrails
03 · CRITIQUE
Red-teams its own answer before you see it.
A second pass asks: what did we miss, what did we over-weight, what alternative explains the same findings? The critique is shown inline — with the option to revise the ranking.
Self-critique catches 34% more diagnostic anchoring
04 · TRACE
Every decision is auditable.
Shows the evidence chain, the guidelines it referenced, and the confidence boundary for each diagnosis. Nothing is a black box — because a clinician has to sign the note.
Reasoning trace exportable per consult
Worked example

Walk through the reasoning — don't just read the conclusion.

Differential surfaces the branch points. You see why it ranked cholecystitis over cholangitis, what investigation would break the tie, and which findings were weighed against each other.

Shows the tree, not just the leaf.
A confident diagnosis without the reasoning is just a guess with extra steps. Differential shows its work.
Expandable evidence chains.
Click any finding to see the study, the guideline, and the confidence boundary it was drawn from.
RUQ pain + fever + CRP↑
Imaging: GB wall thickening?
YES
Acute cholecystitis (0.87)
Plan: US surg r/v, NBM, analgesia
NO / UNCLEAR
Check LFTs + bilirubin trend
→ cholangitis? biliary colic? hepatitis?
Recommend MRCP if trending
reasoning trace · expandable
Never-miss safety net

The point isn't to replace you. It's to catch the things time pressure causes you to miss.

Differential runs a dedicated red-flag pass on every case. Before you close the consult, it asks the question a senior clinician would ask at 3am — calmly, in writing, traceable.

Example rule
New headache + age > 50 + ESR unchecked → flag GCA
Example rule
SOB + bilateral calf swelling → flag bilateral PE workup
Example rule
Unexplained weight loss + iron deficiency → flag colonoscopy
Example rule
Polypharmacy + AKI + NSAID → flag medication review
The evidence

Accuracy you can show the board. Traceability you can show a regulator.

Every claim below is measurable, repeatable, and traceable back to a case file. We publish our methodology.

93%
Top-3 diagnostic accuracy
Benchmarked against 2,400 retrospective cases · attending-reviewed
34%
Reduction in diagnostic anchoring
Critique pass catches over-weighted initial impressions
4.1s
Median time to ranked differential
From FHIR ingest to surfaced reasoning trace
0
Decisions taken without clinician sign-off
Always a draft. Always your call. Always auditable.
Clinicians on Differential

“It's the registrar I never had — one that reads every lab before I walk in.”

The critique pass is what sold us. It surfaces the second-order diagnosis I was going to miss — every time, without making me feel stupid.
Dr Aisha Patel
General Practitioner · Melbourne
I still sign every note. Differential just makes sure the note I sign is the right one. It's defensive medicine without the cost.
Dr James Morrison
Consultant Anaesthetist · Sydney
Ingests from · exports to
Best Practice·MedicalDirector·Genie·Zedmed·Cerner·Epic·HL7 / FHIR·SNOMED-CT
FAQ

Questions clinicians actually ask us.

No. Differential produces a ranked differential with confidence and evidence — a clinician always reviews, edits, and signs. It is decision support, not autonomous decision-making. Every output is a draft.

Low-confidence cases are flagged explicitly, with the specific investigations that would raise confidence. Differential will say “I don’t know, and here’s what would help me know” — we consider that a feature, not a bug.

No patient data is used for model training. Ever. All inference is run against our deployed reasoning engine with per-clinic data isolation. You can see exactly what was sent, when, and why, per case.

Socrates gathers history → Scribe captures the consult → both feed into Differential’s reasoning. You can also run Differential standalone against a patient file at any point. They compose; they don’t require each other.

Differential is clinical decision support, not a diagnostic device. We align with TGA guidance (AU), MHRA (UK), and are pursuing FDA 510(k) for US deployment. Security is SOC 2 Type II, ISO 27001, HIPAA-aligned.

Every case carries a reasoning trace, a confidence score, and a critique log. When a clinician overrides the ranking, we learn which class of case the model struggled with — and publish it quarterly. Transparency is the product.

See Differential on a real case

Bring a case. We'll walk you through the reasoning.

45 minutes. Your referral, your labs, your imaging. You see exactly what the differential produces, how the critique pass works, and where the clinician stays in control.